Grant from NIH to Develop AFM Probes

August 19, 2009

Carbon Design Innovations has announced that it has grant in the amount of $390,000 from the National Institutes of Health (NIH) Small Business Innovation Research (SBIR) Program. The grant will fund the development and commercialization of Carbon Nanotube (CNT) Atomic Force Microscope (AFM) probes for bioimaging and investigations in cellular biology. Carbon Design Innovations will collaborate with the University of California at Davis, US on the development of the probes.
www.carbondesigninnovations.com

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New Bioimaging Method for Observing HPCs

August 13, 2009

timm_schroeder_hpcs

The research team led by Dr. Timm Schroeder, stem cell researcher at Helmholtz Center Munich, Germany has developed a new bioimaging method for observing the differentiation of hematopoietic progenitor cells (HPC) at the single-cell level. With this method the researchers were able to prove for the first time that not only cell-intrinsic mechanisms, but also external environmental factors such as growth factors can control HPC lineage choice directly. The findings, published in Science, provide an essential building block for understanding the molecular mechanisms of hematopoiesis and are an important prerequisite for optimizing therapeutic stem cell applications.

With the new bioimaging techniques developed by Dr. Schroeder’s team, progenitor cells could be observed for a longer period and on the single-cell level. Depending on the kind of cytokines present, after a few days the HPC cultures contained only one cell type. The question remained unanswered whether this was a consequence of direct cytokine regulation or merely the result of sorting out “erroneously differentiated” cells by cell death. Using the new bioimaging techniques for continuous single-cell observation, Dr. Michael Rieger and students in Dr. Schroeder’s research group showed for the first time that no cell death could be detected during the entire cell differentiation process. This proves unambiguously that HPC lineage choices can be steered by external environmental factors such as in this case by cytokines. The hematopoietic progenitor cells are “instructed” by cytokines.
www.helmholtz-muenchen.de

Original publication:
Rieger MA, Hoppe PS, Smejkal BM, Eitelhuber AC & Schroeder T (2009): Hematopoietic cytokines can instruct lineage choice. Science 325:217-218


Euro-BioImaging: First Stakeholder Meeting

Juli 17, 2009

From September 21-22, 2009 the first stakeholder meeting of Euro-BioImaging will take place at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany. The goal of Euro-BioImaging project is to establish a pan-European imaging infrastructure for biological and medical research. It will provide access to state of the art imaging technologies, training and a continuous development of imaging research technologies. The aim of the stakeholder meeting is to gather eminent representatives of the scientific community, funding and governmental organisations, and industry with particular interest in biomedical imaging and to discuss potential participation as well as the content and structure of this infrastructure project. Register online at:
www.embl.de/conferences/eurobioimaging


4th CeBiTec Symposium: BioImaging

Juni 18, 2009

Microscopy has contributed immensely to the development of modern biology since 1665 when Robert Hooke published his book „Micrographia“ depicting a large number of microscopical sketches. In our days a major breakthrough in biology is the discovery of the green fluorescent protein (GFP). Another important innovation was found by the german scientist Stefan Hell from Göttingen. He received for example the „Leibniz Preis“ of the German research community (DFG) for „light microscopy with unknown clarity“. These methods enable the visualization of nanoscopic structures in living cells.

Similar high magnification microscopic plus latest electronmicroscopic techniques are also being developed in the department of physics at the University of Bielefeld. A third building block will lead from August 25-28, 2009 from microscopy to imaging.

The topics include:

– Beyond Optical Microscopy
– High Resolution Microscopy in Biology
– From Life Cell Imaging to Systems Biology
– Bioimaging Informatics

The registration is open until July 11, 2009.

www.cebitec.uni-bielefeld.de/symposium/bioimaging

bioImaging 2009

bioImaging 2009